Urinary Tobacco Alkaloid Measurement in Patients Having Thromboangiitis Obliterans–Reply–I

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Thromboangiitis obliterans.

Case presentation: A 39-year-old male smoker with a 2-year history of calf discomfort on ambulation culminating in left femoral-to-peroneal artery bypass presented with right leg discomfort and recurrent painful subcutaneous nodules on his feet and calves. Biopsy of a nodule from his right foot was interpreted as vasculitis with thrombosis and fibrinoid necrosis in subcutaneous vessels, and the...

Circulating Angiogenic Factors in Patients with Thromboangiitis Obliterans

BACKGROUND Thromboangiitis obliterans (TAO, also known as Buerger's disease) is a non-atherosclerotic inflammatory vascular disease that primarily affects arteries in the extremities of young adult smokers. Since the etiology of TAO is still unknown, therapeutic options are limited. Recent attempts in therapeutic angiogenesis have been promising. Therefore, the aim of our study was to evaluate ...

Thromboangiitis obliterans.

Thromboangiitis obliterans (TAO) has been a recognized clinical entity for more than half a century (Buerger, 1908). Distal arterial occlusive disease and/or recurrent superficial thrombophlebitis occurring in an adult male smoker, in the absence of known cause, constitutes a distinctive and unmistakable syndrome (Brown, Allen, and Mahorner, 1928). However, the existence of this disorder has be...

Tobacco nicotine uptake permease (NUP1) affects alkaloid metabolism.

An effective plant alkaloid chemical defense requires a variety of transport processes, but few alkaloid transporters have been characterized at the molecular level. Previously, a gene fragment encoding a putative plasma membrane proton symporter was isolated, because it was coordinately regulated with several nicotine biosynthetic genes. Here, we show that this gene fragment corresponds to a N...